Peptides Archives - sarmguide

IGF-1 LR3 Review, Benefits, Dosage | December 2023

sarmadmin — Wed, 09 Nov 2022 15:24:51 +0000

Many bodybuilders are interested in IGF-1 LR3, as it’s a better and more metabolically stable version of IGF-1.

Some even claim that the former has less side effects, which is a common misconception.

In this IGF-1 LR3 review, we’ll be looking at the purported benefits of the compound, dosages, side effects and so on.

What is IGF-1 LR3

IGF-1 LR3, also written as long arginine 3-IGF-1 is an artificial protein and extended version of IGF-1.

We’ll discuss differences and why IGF-1 LR3 is often touted as the better option in a subsequent chapter.

IGF-1 LR3 is special since it has an arginine amino acid in its composition, which should lead to more protein in the body.

Reason being that arginine is a common component of protein, helping the body not only build but also absorb more protein from exogenous sources.

All this leads proponents to believe IGF-1 LR3 to be a potent muscle builder.

As we’ll later see, a common problem presents itself with IGF-1 LR3; lack of human studies.

How Does It Work

IGF-1 LR3 should work just the same as regular IGF-1, with the added benefit of lasting longer in the body, being more potent and so on.

To recap, IGF-1 is a protein modulated by GH (growth hormone).

It’s most active during growth spurts in puberty, which is why many people ask whether IGF-1 can make them taller later in life.

When taken recreationally by adults, IGF-1 exhibits anabolic effects.

Basically, it promotes growth in every cell of the body but it also inhibits programmed cell death, which is why some researchers are concerned about IGF-1 causing cancer.

IGF-1 primarily works by binding to IGF-1R, a receptor crucial for the metabolic and proliferative effects of the former.

IGF-1, with the help of GH, also modulates the amount of insulin in the body.

Is IGF-1 LR3 Legal

While I haven’t seen IGF-1 LR3 listed on the WADA or USADA form of prohibited substances, IGF-1 is present and is completely banned.

It’s only natural that not all derivatives and analogues of IGF-1 are listed, meaning that IGF-1 LR3 is illegal in competitive sports and competitions.

However, if you’re just a regular bodybuilder, there’s nothing stopping you from getting IGF-1 LR3 for research purposes.

With the advent of the internet, you can find pure and tested IGF-1 LR3 in just a few minutes.

Near the end of the article, I’ll show you my favorite places to buy pure peptides.

IGF-1 LR3 Benefits

Please note that many websites try to swindle their readers by equalizing the effects of IGF-1 and IGF-1 LR3.

While they are similar, there are no human studies showing the effects of IGF-1 LR3.

They are all either cellular or done on rats or other animals.

With that being said, here are the purported effects of IGF-1 LR3!

1. IGF-1 LR3 Increases Muscle Mass

Based on what we know about IGF-1 LR3, it should act just as injected IGF-1 in the body and exhibit anabolic effects.

The biggest proponent of this claim is this study, which showed anabolic effects in dexamethasone-treated rats.

For the record, dexamethasone is a popular medication used to treat skin diseases and similar ails.

What’s interesting about the study above is that analogues of IGF-1, like IGF-1 LR3, have been shown to be up to 2.5 times as potent in the rats!

This is great news, provided the effects of IGF-1 LR3 on animals translate on to humans.

2. IGF-1 LR3 Increases Metabolic Rate

A human’s metabolic rate determines how much energy (calories) he will expend during a set period of time.

Given that normal IGF-1 increases metabolic rate in humans, the same should apply to IGF-1 LR3.

We all know that muscle mass indirectly impacts our metabolism.

With that being said, cutting should be made much easier given the potency and metabolic activity of IGF-1 LR3.

3. IGF-1 LR3 Increases Fat Loss

Weight loss and therefore, fat loss has been associated with increased IGF-1 levels.

While no studies have shown a direct link between IGF-1 LR3 and fat loss, many anecdotal reports confirm the notion.

IGF-1 LR3 should be good for cutting weight and fat, given its previously mentioned metabolic activity.

However, you do need to put some work in, the compound won’t do the heavy lifting alone.

4. IGF-1 LR3 Build Bones, Increases Bone Strength

There’s a very interesting paper on this subject, showing that IGF-1 had very good effects on bone strength, growth and density in animal models.

Not just that but IGF-1 has been shown to mediate the above throughout life, not just during puberty.

We all know that bones are the foundation of big muscles.

While there are no direct studies confirming this effect on IGF-1 LR3, once again, anecdotal reports speak in favor.

5. IGF-1 LR3 Increases Sleep Quality

Good sleep is associated with increased muscle mass.

Although the relationship between IGF-1 and sleep are poorly understood, scientists believe it has to do with orexin neurons.

Many people reported better and higher-quality sleep after receiving IGF-1 injections.

As previously stated, most of the studies presented in this article are on actual IGF-1.

Reason being the lack of information on IGF-1 LR3; even when studied, it’s often grouped together with IGF-1 and other derivatives.

Please don’t assume that IGF-1 LR3 will have the same effects in the body as IGF-1.

IGF-1 LR3 Dosage

Judging from anecdotal reports, people inject anywhere between 30 to 200mcg per day.

From a personal standpoint, everything beyond 100mcg is a bit too much and carries more risk of side effects.

Reason being the dose-dependent effects of IGF-1 LR3; the more you take, the harder it hits.

A sweet spot would be 50mcg per day for the next six to eight weeks.

If you’re a newbie, stick to six weeks and see how your body is reacting to the compound.

IGF-1 LR3 usually comes in 1mg denominations.

This means that a 1mg bottle of IGF-1 LR3 should last you 20 days provided you inject the recommended 50mcg dosage.

Also important to mention is that IGF-1 LR3 is best injected either subcutaneously or intramuscularly, depending on preference.

IGF-1 LR3 Half-Life

According to this study, IGF-1 LR3 has a half-life of 20 to 30 hours.

The reason why it takes so long for IGF-1 LR3 to leave the body is decreased binding to insulin-like growth factor-binding protein (IGFBP).

The latter regulates the activity of IGF-1, oftentimes decreasing it as the body notices exogenous IGF-1 present in tissues.

IGF-1 LR3 Side Effects

Since it’s agreed that IGF-1 LR3 is basically a more potent analogue of IGF-1, the side effects are nothing to scoff at.

I’m here talking about proliferation of malfunctioning cells (cancer), protruding gut (“GH gut”), diabetes and so on.

Let’s look at the top three side effects of IGF-1 LR3 and see what the fuss is all about.

1. IGF-1 LR3 Causes Cancer?!

I already penned an interesting article on the topic surrounding MK-677 and cancer.

For those left out of context, MK-677 is a GH secretagogue that increases IGF-1 levels.

With the data we have right now, there’s no definitive proof IGF-1 LR3 causes cancer.

However, you have to beware of IGF-1 and its effects on existing tumors, as it has been proven to promote cancer development.

Basically, don’t use it if you have cancer.

In all other instances, you’re more than likely going to be just fine.

2. IGF-1 LR3 Causes GH Gut?!

If you’ve watched bodybuilding shows from the 90’s, you have probably noticed some of the contestants having a protruding gut.

Around the same time, IGF-1 injections entered the professional scene.

Was that a mere coincidence or is there something to it?

The thing is, GH gut is most often caused by either insulin resistance or an unhealthy diet.

The former can be caused by IGF-1, especially if the person in question is using it long-term.

With the added power of IGF-1 LR3, there seems to be a real concern about developing GH gut.

My recommendation is to cycle IGF-1 LR3 and not take it for more than eight weeks.

That should offset the chances of developing GH gut.

3. IGF-1 LR3 Causes Diabetes?!

An interesting review of research papers states that IGF-1 may have a future in treating some types of diabetes.

Both low and high IGF-1 levels are linked to insulin resistance which may lead to diabetes.

This is an obvious problem for people that constantly keep their IGF-1 levels high through exogenous compounds.

However, for someone cycling IGF-1 LR3, there shouldn’t be any problems.

IGF-1 LR3 VS IGF-1

While many online sources will tell you that the two compounds above are similar, there are some important differences between them.

IGF-1 has 70 amino-acids in total, while IGF-1 LR3 has a total of 83.

Not only that but IGF-1 LR3 has been shown to be more resilient to IGFBP, which leads to the heightened half-life of the former.

In cellular and animal studies where IGF-1 and IGF-1 LR3 were put to the test, the latter consistently outperformed IGF-1 by two to three times.

Last but not least, IGF-1 LR3 has improved metabolic stability compared to IGF-1.

Where to Buy IGF-1 LR3

Conventional IGF-1 is still too expensive.

On the other hand, its analogue, IGF-1 LR3 is less than 100$ in most shops.

You’re usually bestowed with 1mg of the compound which is enough for around 20 days of administration.

I tested many online sources and came up with a list of recommended peptide vendors.

These companies go above and beyond but most importantly, they have pure and laboratory tested IGF-1 LR3.

Don’t forget that IGF-1 LR3 is injected, so ensure that you have proper and sterilized equipment if you’re going to use it.

Conclusion

I haven’t tried IGF-1 LR3 personally, as I’m waiting for some human studies to crop up.

What this IGF-1 LR3 review has shown us is that there’s more to this peptide than meets the eye.

It’s downright criminal to assume that a synthetic analogue is equivalent to the real deal, keep that in mind before you consider IGF-1 LR3 usage.

The post IGF-1 LR3 Review, Benefits, Dosage | December 2023 appeared first on sarmguide.

SARMs VS Prohormones | A Comprehensive Comparison

sarmadmin — Tue, 08 Nov 2022 15:11:47 +0000

Both SARMs and prohormones are powerful PEDs (performance-enhancing drugs) that can help you achieve your goals.

There are some differences between the two and in this article, I will present both of these compounds in an objective manner.

We will put them side by side and see how they perform against each other when it comes to benefits, side effects, pricing and so on.

What Are SARMs

SARM is an acronym standing for selective androgen receptor modulator; they are androgen receptor ligands.

This means that they selectively bond to the androgen receptor and exert effects usually associated with steroids but without all the side effects of the latter.

While this implies SARMs would be an excellent choice for muscle wasting diseases such as osteoporosis, not one SARM has been approved by the FDA.

Despite that, thousands of men use SARMs for their muscle-building properties as well as their ability to add strength, bone density, etc.

Some of the most popular SARMs are Ostarine, Ligandrol and RAD 140.

What Are Prohormones

As the name implies, prohormones are literally “for hormones” in the sense that they are precursors to actual hormones in the body.

This essentially means that you could be taking a completely legal prohormone, without a prescription, and later watch it turn into pure testosterone in the body!

Needless to say, not all prohormones are androgen prohormones but it’s only natural that these substances are amongst the most popular choices.

Prohormones used to be widely popular in the US before President Bush and later President Obama, signed acts which made them both illegal to manufacture and distribute.

The most popular prohormones are 1-Androsterone, Arimistane and Epiandrosterone.

SARMs VS Prohormones | Ease of Access

While most prohormones are essentially illegal, some of them slipped through the cracks and are in a gray area, like SARMs.

I’m not going to pretend that prohormones, even illegal ones, are hard to get.

In reality, they are just a few clicks away.

While I obviously don’t condone such behavior, it’s important to note that the reason why you shouldn’t go for the illegal ones is lack of quality control.

These vendors who peddle prohormones on the black market get this stuff in bulk from China.

Trust me, they don’t give two damns about your health and are mostly there to make a quick buck.

On the other hand, the legality of SARMs is still unclear, which means you will have no trouble buying them online.

All in all, SARMs are the better option here as they have some quality control and vendors aren’t breaking the law by selling them.

SARMs VS Prohormones | Benefits

The truth is, even the strongest SARM, I’m thinking of S23 in this instance, is still less potent than the weakest prohormone.

The reason for that is obvious; prohormones are quasi-steroids!

With SARMs, you’ll get increased muscle mass, strength, energy levels and so on.

However, prohormones will do all that but at a higher intensity.

This means that you’ll get bigger and better results using prohormones compared to SARMs.

Prohormones are the clear winner here.

SARMs VS Prohormones | Route of Administration

While some people unfamiliar with prohormones might think they are necessarily injected, that’s not quite right.

Prohormones can be taken orally, which might seem convenient but side effects such as increased hepatotoxicity are a real problem.

On the other hand, SARMs can be taken orally, injected and sublingually.

To be quite fair, there isn’t a clear winner here when we strictly look at the options presented.

However, I skew towards SARMs as their proclivity for liver damage is far lower compared to prohormones.

SARMs VS Prohormones | Side Effects

I’ve already described SARMs as the weaker PED in a previous chapter but what about side effects?

Contrary to popular belief, SARMs may or may not have a lot of side effects.

It all depends on the SARM and dosage taken.

For example, if you’re a newbie to SARMs and take 20mgs of YK11 per day, it’s only natural that you’ll experience a myriad of adverse effects.

However, if you pre plan your cycle, research your options, do your due diligence, you’re very likely to have a good time.

On the flip side of the coin, prohormones have side effects like gyno, aggression, testicular atrophy, acne, hair loss…

While some of the stronger SARMs can also have these effects, they won’t be as pronounced as in prohormones.

In conclusion, SARMs have a better side effect profile and therefore take home the bacon.

SARMs VS Prohormones | Pricing

The prices of SARMs and prohormones vary quite a lot depending on your vendor.

An average monthly supply of SARMs will set you back around 55$, give or take.

It’s a similar story with prohormones, although prices might vary massively depending on your source.

To be perfectly fair, you shouldn’t look at the price tag of the compounds you’re imbuing.

After all, it’s expected that the higher the price tag, the better the product and service.

Therefore, this entire pricing debacle is pointless.

There are no winners here, although I would never risk buying prohormones on the black market in fear of legal repercussions.

Conclusion

In a perfect world, both SARMs and prohormones would be completely legal and people would have the liberty to decide what and when to take.

That obviously isn’t the case.

For that reason, I prefer SARMs as they are still legal and easy to buy at my recommended companies.

The post SARMs VS Prohormones | A Comprehensive Comparison appeared first on sarmguide.

Fragment 176-191 Review, Benefits, Dosage | December 2023

sarmadmin — Mon, 07 Nov 2022 17:12:55 +0000

When fat loss is concerned, Fragment 176-191 is being tossed around as the perfect peptide for the job.

While studies on this peptide are scarce, there are plenty of anecdotal reports featuring its effectiveness.

This Fragment 176-191 review will tell you the exact benefits you can expect from this peptide, along with:

What is Fragment 176-191
Is Fragment 176-191 legal
The best Fragment 176-191 dosage
Fragment 176-191 side effects you can expect
…and much more!

What is Fragment 176-191

Fragment 176-191, also known as HGH Frag and Somatotropin 176-191 is just what the name implies, a fragment chain of a bigger peptide hormone.

To understand what that means, we have to consider the amount of amino-acids HGH (human growth hormone) has.

The exact number is 191, implying that Fragment 176-191 constitutes the last 16 amino-acids of HGH.

While some may think this means Fragment 176-191 will have similar effects as HGH, that’s not exactly the case.

The reason behind this is not currently known, since studies on this fragment chain are scarce.

How Does It Work

The exact mechanisms by which Fragment 176-191 exerts its influence are unknown but we do know it causes lipolysis in the body.

This leads to the fat loss many bodybuilders exhibit after taking the compound.

What’s interesting about Fragment 176-191 is that it doesn’t induce high blood pressure or high blood sugar via its mechanism of action.

This effect has only been observed in mice and it’s questionable whether it translates onto humans.

Another study on rats observed glucose reduction and reduced insulin sensitivity.

In the future, Fragment 176-191 may have potential to be a supplementary treatment option for diabetes type 2.

All in all, there are no studies observing the function of Fragment 176-191 in humans.

This means that we have no idea how this peptide actually works, so tread with caution.

Is Fragment 176-191 Legal

Fragment 176-191 is included in the WADA list of prohibited substances under section S2 (2.3).

The aforementioned section lists ALL HGH fragments and analogues as illegal, just because some fragments aren’t mentioned by name, doesn’t make them legal to use.

The truth is, if you’re competing, don’t go near HGH, its fragments or any analogues.

They test for that quite extensively and it’s more than likely you’ll get caught.

However, if you’re a regular bodybuilder or just a person that wants to improve his physique, Fragment 176-191 can be bought online.

Keep in mind that Fragment 176-191 is meant for research purposes and you should only buy it for research purposes.

Avoid vendors offering this or any other peptide under the guise of human consumption.

Keep reading and at the end of the article, I’ll show you my favorite peptide stores.

Fragment 176-191 Benefits

Before listing all the benefits of this peptide, I would like to remind you that no research on humans has been performed using Fragment 176-191.

This means we have no idea how it actually works on humans.

While there are many anecdotal reports of people taking Fragment 176-191, they don’t give an accurate picture of what really goes on.

1. Fragment 176-191 Increases Fat Loss

The main reason why so many bodybuilders are jumping on the Fragment 176-191 train is best described by the following phrase: “It burns fat, without all the sides of HGH!”

As previously mentioned, Fragment 176-191 induces lipolysis; a process where triglycerides are broken down into fatty acids, an energy source.

The biggest problem with HGH is that it may cause water retention and other unpleasant side effects.

With Fragment 176-191, it’s a thing of the past, at least that’s what anecdotal reports say.

2. Fragment 176-191 May Induce Fat Redistribution

This is purely anecdotal but many bodybuilders have said that Fragment 176-191 is great for body recomping.

Not only do you lose fat but you also recomp in a way where the fat from your lower abdomen and face is redistributed to other areas.

The great thing about Fragment 176-191 is that it doesn’t affect a biochemical process called carbohydrate metabolism.

Basically, the energy supply chain of your body is not interrupted.

3. Fragment 176-191 May Promote Cartilage Regeneration

Without a doubt, our cartilage is one of the most important parts of the body, protecting bones and joints alike.

Fragment 176-191 apparently has the ability to induce cartilage regeneration and may be used for osteoarthritis.

This has only been studied on rabbits so take it with a grain of salt.

Not just that, Fragment 176-191 wasn’t even used in the research but a similar compound, AOD9604!

This is the biggest problem with Fragment 176-191, it basically has no research backing it up.

4. Fragment 176-191 May Regulate Blood Sugar Levels

Six fragments of HGH were put to the test and it turned out Fragment 176-191 had the best results when it came to regulating blood sugar levels.

The hypoglycemic effects came from the C-terminus.

This was a rat study but it may have future implications as referenced before, especially for diabetes type 2.

5. Fragment 176-191 May Increase Energy Levels

This is just bro-science at this point but I have to mention it in case someone does experience increased energy levels from this peptide.

The lipolysis from Fragment 176-191 creates fatty acids, which are a great energy source.

From that point out, it should be obvious why this peptide increases energy levels, especially in human beings prone to an active lifestyle.

Fragment 176-191 Dosage

Since there have been no human studies done with Fragment 176-191, it’s hard to give an accurate dosage from a scientific standpoint.

Bodybuilders who take it recreationally usually do between 150 to 300mcg per injection.

Given that most bodybuilders who take Fragment 176-191 inject it three times per day, you can expect to spend between 450 to 900mcg per day.

Newbies usually start with the lowest dosage and work their way up.

Fragment 176-191 is usually cycled every four to six weeks, the exact time frame depending on the amount of experience you have with the compound and tolerability.

Fragment 176-191 bought online comes in powder form and you have to reconstitute it with the help of BAC (bacteriostatic water).

Don’t worry, the vendors I have personally vetted have BAC in stock.

Fragment 176-191 Half-Life

The half-life of Fragment 176-191 is currently unknown.

There are some websites saying peak concentration is reached within 15 minutes and that the half-life is around 60 minutes.

However, those are studies that have been performed on animals.

We have no idea how Fragment 176-191 would act on an actual human being.

Fragment 176-191 Side Effects

While many websites and bodybuilders claim that Fragment 176-191 doesn’t have any side effects due to its constitution, I would beg to disagree.

The fact that there are no human studies is already established.

However, what many people forget is that there’s a whole umbrella of user experiences who’ve taken Fragment 176-191.

Some said they didn’t feel anything at all for the entirety of their cycle.

Others say they magically lost fat even while on a caloric surplus.

The problem is, we can’t simply give weight to any one opinion or experience with the compound.

From what I’ve seen, the most common complaint from people using Fragment 176-191 is nausea.

Funny thing is, a vast majority of people who’ve actually taken this peptide say they wouldn’t do it again, mostly due to lack of value for money.

Fragment 176-191 VS HGH

We already know that Fragment 176-191 is the end part of HGH, specifically, the last 16 amino-acids.

However, it’s also important to note that while Fragment 176-191 might reduce fat in a dose-dependent manner, HGH does so much more!

HGH can increase muscle mass, bone density, exercise capacity, speed up healing and so much more.

It also has a lot of research behind it, unlike Fragment 176-191, which is essentially a gamble.

Where to Buy Fragment 176-191

If you’re still hellbent on buying Fragment 176-191, at least do so from the right sources.

I have gone through hundreds of peptide vendors and while there are many who claim to be the best, only a handful are worth their salt.

Visit my recommended list of peptide vendors to get the best peptides on the market.

They are 100% pure and the quality control (lab testing) is on point.

Conclusion

While there’s no doubt in my mind Fragment 176-191 is an interesting compound, I haven’t and won’t be taking it until there are some human studies.

Fat loss can be facilitated by keeping your diet in check and training hard; in most cases, there’s no need for an exogenous fat loss agent.

To conclude this Fragment 176-191 review, a peptide without any human research behind it and limited functionality.

The post Fragment 176-191 Review, Benefits, Dosage | December 2023 appeared first on sarmguide.

PT 141 Review, Benefits, Dosage | December 2023

sarmadmin — Fri, 04 Nov 2022 17:17:59 +0000

PT 141 caught my eye after I heard statements saying it’s a better sildenafil (Viagra) and that it can cause erections where Viagra and similar PDE5 inhibitors fail.

This is quite a bold claim and throughout this article, you’ll see that things aren’t quite as good as they are presented to be.

This PT 141 review will show you exactly why you should stick to tried and tested options in almost all cases.

What is PT 141

PT 141, also known as Bremelanotide and Vylessi, is a synthetic peptide drug and melanocortin receptor agonist which causes arousal in both male and female subjects.

It was initially tested for being a sunless tanning agent but the study quickly took a left turn when male subjects experienced spontaneous erections.

As with most other peptides, the effects of PT 141 are dose-dependent; the more you take, the harder it will hit.

PT 141 was isolated from Melanotan II, a discontinued peptide which was found to be loaded with side effects.

The main difference between PT 141 and other popular sexual enhancement products is their mechanism of action.

PT 141 stimulates the central nervous system, completely ignoring blood circulation.

This is the reason why many users report additional benefits with PT 141 compared to traditional ED (erectile dysfunction) medications.

How Does It Work

PT 141 acts on the melanocortin receptor, creating supraphysiological amounts of melanocortin MC4 among others.

This receptor is responsible for regulating sexual function and food intake.

This is the reason why many people using PT 141 frequently report weight loss as a “side effect”.

PT 141 is a peptide analogue of alpha-Melanocyte-stimulating hormone (α-MSH), a full agonist of the aforementioned receptors.

Given this unique mechanism of action, many people surmise that traditional side effects such as nausea, vomiting and high blood pressure are avoided.

However, what anecdotal reports and clinical trials show is that while PT 141 is well-tolerated, it can cause heavy nausea and other adverse effects.

Is PT 141 Legal

While PT 141 has gone on to become an FDA approved medication for the treatment of female sexual arousal disorder, it’s obviously a hurdle to get it as a male.

The brand name, Vylessi, is a prescription medication and trust me, no doctor is going to bother prescribing it to a man.

That’s not a big deal as you can safely buy PT 141 from the comforts of your home.

One thing to keep in mind is that PT 141 is legal but only if you’re buying it as a research chemical.

Imagine PT 141 as the “raw” form of Vylessi, where the former is only meant for research purposes, while the latter is the real deal.

In reality, they are both the same peptide.

To conclude, yes, you can get PT 141 online but only if you’re buying it for research purposes.

PT 141 Benefits

The interesting thing about PT 141 is that many users have reported strange benefits, including an increased sense of sensation and better sex.

While no studies looked into this, it’s an interesting thing since the aforementioned melanocortin receptors mediate a lot of things in the body.

Without further ado, here are the benefits of PT 141!

1. PT 141 Increases Libido In Healthy Men And Women

There are many sites out there saying women shouldn’t use PT 141 without really providing a reason.

The funny thing is, the brand drug is literally approved for treating female sexual problems unrelated to psychiatric problems or postpartum depression.

Essentially, it should work on healthy women as well as men.

One study showed that administering PT 141 to healthy men led to a dose-dependent increase in libido.

Another paper which dealt with both healthy males and those suffering from ED found that PT 141 once again increased libido in a dose-dependent manner.

The men from the aforementioned were already responsive to Viagra; one would think mentioning the study is unnecessary.

However, when you consider that PT 141 and Viagra can be stacked for even bigger and better erections, the picture becomes clearer.

For those worried about side effects, this study said it was perfectly safe and that both compounds were well tolerated.

2. PT 141 Increases Libido In Men Affected By ED

Most studies where participants had mild to heavy ED were done in conjunction with Viagra.

This means that it’s very hard to tell whether PT 141 alone would work against ED.

We do have this double-blind placebo controlled study that looked into patients with mild to moderate ED.

While many HEALTHY proponents tout the long-lasting effects of PT 141, men with ED usually have their erections cut down at the one-hour mark.

Compared to Viagra, one could make the claim that PT 141 lasts four times shorter, on average, in men with ED.

However, if you’re someone with ED and traditional PDE5 inhibitors haven’t worked, PT 141 is a good alternative due to its unique mechanism of action.

3. PT 141 Enriches Sexual Experiences

This is purely anecdotal and there are no studies looking into this.

Many men who have used products like Viagra or Cialis report that PT 141 made them feel special, almost high, 45 to 60 minutes after injection.

Apparently, sensations are heightened and sex is more pleasureable.

The community is divided on PT 141 and its “special” effects, as the alleged benefits seem to be on a case by case basis.

4. PT 141 May Work Where PDE5 Inhibitors Fail

As already mentioned, PT 141 is often studied in conjunction with PDE5 inhibitors so it’s hard to gauge how true the above statement is.

If you’re someone that has exhausted all traditional options, PT 141 might do the trick due to its unique mechanism of action.

To be fair, PDE5 inhibitors work on the vast majority of people struggling with ED but when they fail, PT 141 comes in as a good, albeit inferior, replacement.

5. PT 141 May Cause Weight Loss

I was hesitant to include this benefit as PT 141 should never be used solely for weight loss.

Yes, PT 141 does modify your eating patterns but it’s simply unsustainable to inject yourself with it just to lose weight.

Working on the quality of your diet and caloric intake is literally 90% of the battle.

PT 141 Dosage

You’ll often hear that PT 141 can both be used intranasally or injected, depending on preference.

What is conveniently left out is the atrocious bioavailability of PT 141 when taken intranasally.

Some sources cite that you need up to ten times the amount of PT 141 just to get the same effects when using it intranasally.

Therefore, injecting it is a no-brainer.

With that out of the way, 1 to 2mgs of PT 141 is usually injected 45 to 60 minutes before intercourse.

Please note that when you buy PT 141, it will come as a power and you’ll need to dilute it with bacteriostatic water (BAC).

Don’t worry, all the vendors featured at the end of this article feature pure PT 141 and BAC.

If you’re worried about side effects or are a complete beginner to peptides, starting out with 500mcg is also fine.

PT 141 Half-Life

Interestingly enough, many sites and vendors claim that PT 141 lasts “for up to 8 hours” and that you’ll be able to party all night.

This is only true when PT 141 is used by HEALTHY subjects, men with ED usually don’t experience erections beyond the one hour mark.

Besides, the mean half-life of PT 141 is between 1.9 to 4 hours, averaging at 2,7 hours.

PT 141 Side Effects

The biggest side effects of PT 141 are nausea, headaches and flushing.

Rarely will you see people throw up after injecting or experience an increase in blood pressure.

Despite that, people with elevated blood pressure should under no circumstances use PT 141 as it presents a real health hazard.

Other than that, PT 141 has shown great tolerability in studies, even when used in higher dosages.

PT 141 VS Melanotan 2

Some people think these two compounds are one and the same but there are a couple of differences.

The first thing to mention is their side effect profile; PT 141 is much safer to use.

In fact, all clinical trials using Melanotan 2 ceased as early as 2003.

Reasons cited are the enlargement of already existing moles, proliferation of new moles and uneven pigmentation.

While this doesn’t sound so scary at first, melanoma (skin cancer) is a real concern, especially with overgrown moles.

Personally speaking, I wouldn’t touch Melanotan 2 with a 10 foot pole.

The crucial difference between these two peptides stems from the fact that PT 141 has a hydroxyl group instead of an amide.

Also, it’s good to know that PT 141 was actually isolated from Melanotan 2.

Where to Buy PT 141

You have to be really careful with this stuff, only buy from reputable vendors.

I have never tried PT 141 personally but if Viagra and Cialis ever failed to do the trick, I could see myself giving it a shot.

However, I would still think about it as the side effect profile of PT 141 is more pronounced compared to traditional PDE5 inhibitors.

If you still want to buy PT 141, have a look at my recommended list of peptide vendors.

The companies listed above have all been vetted and are legitimate peptide distributors.

Conclusion

PT 141 is a very interesting peptide and it deserves far more publicity.

However, what this PT 141 review has shown us is that it’s not a good substitute for traditional PDE5 inhibitors.

If Viagra or Cialis do start failing you, PT 141 could come to the rescue; otherwise, it’s just an inferior option.

The post PT 141 Review, Benefits, Dosage | December 2023 appeared first on sarmguide.

GHRP-2 Review, Benefits, Dosage | December 2023

sarmadmin — Thu, 03 Nov 2022 16:53:42 +0000

GHRP-2 is a very interesting compound, it’s basically fresh on the market and many compare it to the similarly named GHRP-6.

If you’re looking for ways to increase mass, sleep better and improve your overall body composition, then GHRP-2 should be considered.

In this GHRP-2 review, I’ll be showing you:

What is GHRP-2
Is GHRP-2 legal
Best GHRP-2 dosage
Side effects of GHRP-2
…and so much more!

What is GHRP-2

GHRP-2 (growth hormone releasing peptide 2), also known as Pralmorelin among others, is a synthetic peptide and GHSR (growth hormone secretagogue receptor) agonist.

In layman terms, it increases GH (growth hormone) levels and successfully induces hunger in humans.

This peptide drug has been used for safe assessment of GH deficiency and it even had some phase II trials for treating short stature.

GHRP-2 is also very structurally similar to met-enkephalin, considered an OGF (opioid growth factor).

This is important because OGFs have very low bioavailability and last a very short time.

The question is, does GHRP-2 improve on these shortcomings and if yes, can we expect opioid-like effects from GHRP-2 consumption?

Unfortunately, the answer is no but GHRP-2 does have some other interesting benefits which I’ll explore in a subsequent chapter.

How Does It Work

As the name implies, GHRP-2 binds to the growth hormone secretagogue receptor, acting as an agonist.

Since GHRP-2 is a synthetic agonist of ghrelin, it induces hunger in the subject and secretes growth hormone (GH) on a supraphysiological level.

GHRP-2 is known as a “second generation” GHRP, since it releases more GH in the body, while inducing less hunger than its predecessor, GHRP-6.

While most effects of GHRP compounds have been studied on animals, GHRP-2 is one of the few that has an actual human study behind it.

In that study, seven healthy males showed increased GH levels after GHRP-2 administration.

Not just that, they also consumed 35.9% more calories compared to baseline.

This tells us that GHRP-2 might be a valuable tool for bulking in bodybuilders.

However, the study presented above has some limitations; small sample size being the most obvious.

Is GHRP-2 Legal

GHRP-2 and similar synthetic peptide drugs are all banned on both the WADA and USADA lists of prohibited substances.

This means that taking GHRP-2 if you’re actively competing or are an athlete will more than likely lead to a full exclusion from all tournaments.

Take the example of Chad Mendes, who received a two-year suspension for abusing GHRP-6.

Other than that, if you’re a regular bodybuilder, GHRP-2 is appropriate as long as you buy it as a research chemical.

Nowadays, it’s quite easy to get your hands on real GHRP-2 via the power of the internet.

At the end of the article, I will show you my favorite GHRP-2 sources!

GHRP-2 Benefits

GHRP-2 is still quite new and doesn’t have a lot of research behind it.

The one human study you saw featured before simply isn’t enough to warrant its usage.

However, if you’re open for experimentation, here are the benefits you should expect from GHRP-2.

1. GHRP-2 Improves Sleep Quality

Many anecdotal reports claim that they’ve had “the best sleep of their lives” after administering GHRP-2.

The good news is that GHRP-2 doesn’t have a loading phase, which means you’ll notice its effects soon after injecting.

While there are no studies supporting these claims, one paper looked at GHRP-6 and its effects on sleep.

The study concluded that GHRP-6 had the ability to enhance non-REM sleep.

When you consider GHRP-2 is basically an improved version of GHRP-6, one can see how the effects translate from the latter onto the former.

2. GHRP-2 Helps Build Mass

Please note that you won’t necessarily gain muscle mass from GHRP-2; it doesn’t have anabolic effects in humans.

What will surely happen is increased hunger and subsequently, increased food consumption.

Sometimes, this can lead to unpleasant outcomes; if your diet is bad, you’ll not only increase the risk of gastric motility but also increase the chances of diabetes and so on.

You need to pre-plan your meals and be ready for hunger pangs in advance.

To conclude, GHRP-2 enables those that have problems gaining mass to do just that.

However, what type of mass it will be is entirely dependent upon you.

3. GHRP-2 Improves Recovery Times

GHRP-2 does improve recovery times but it’s nothing significant.

No studies looked into this supposed benefit but many bodybuilders did report it after GHRP-2 administration.

Take from that what you will.

4. GHRP-2 Reduces Body Fat

Many bodybuilders praise GHRP-2 for its ability to reduce fat in critical areas of the body.

Even while in a caloric surplus, you will lose fat around the face, midsection, calves, etc.

This is due to lipolysis, a process where triacylglycerols, through which fat is stored in the body, are broken down to simpler molecules.

This has been confirmed in the following study.

5. GHRP-2 Improves Skin Health

It’s only natural that GHRP-2 improves skin health, since it releases GH, which is known to affect skin tissues in a positive way.

Although there’s limited research in support of these claims, almost every bodybuilder out there speaks about the positive effects of GHRP-2 on their skin.

Less wrinkles, tightened skin and a sort of “glow” are just some of the benefits of GHRP-2.

GHRP-2 Dosage

The most common GHRP-2 dosage is between 100 to 300mcg per injection.

This means that you’re spending anywhere from 0.5mg to 1.5mg of GHRP-2 per day, given a five time injection protocol.

Given the fact that 5mgs of GHRP-2 costs around 20$ in most stores, you’ll be spending between 2 to 6$ on this peptide alone.

Granted, it’s not a lot of money but what I’m really concerned about is the frequency of injections.

GHRP-2 Half-Life

One reason why GHRP-2 is a bit of a pain in the neck is its absurdly low half-life of just 30 minutes.

According to the study above, peak GH levels are reached 15 minutes into injection.

This means GHRP-2 has to be taken several times per day to be effective.

I’ve heard of people injecting up to five or even ten times per day, which is just ridiculous and a possible health hazard due to infections.

GHRP-2 Side Effects

The most concerning thing about GHRP-2 isn’t the peptide itself but the possibility of unintentional self-harm due to injection frequency.

I’m talking about pain, tenderness, swelling, redness around the area and so on.

In itself, this doesn’t present a problem but given the fact that you have to keep injecting to enjoy the effects of GHRP-2, you’re not giving your skin enough time to recuperate.

This can exacerbate the effects mentioned above.

Not to mention that you’ll most likely not be under medical supervision during injecting, which may lead to additional injuries.

The real side effects of the drug boil down to hot flashes and sweating, nothing particularly concerning.

GHRP-2 VS GHRP-6

You’ll often hear people claim GHRP-2 to be the superior peptide but I beg to disagree.

They both have their strengths and weaknesses; for example, GHRP-6 is better if you have trouble gaining weight.

On the other hand, GHRP-2 releases more GH in a shorter time period compared to GHRP-6.

GHRP-6 has a longer half-life than GHRP-2 and therefore doesn’t need to be injected five times a day to feel the full effects.

GHRP-2 is only considered more potent given the fact it releases a high amount of GH but that’s offset by its short period of duration.

Last but not least, GHRP-2 is often touted as a much safer compound side-effect wise.

This is correct if you only take the effects of these two peptides into consideration; GHRP-6 may increase prolactin, cause water retention and gastric motility.

However, when you consider the risks of amateur bodybuilders injecting GHRP-2 five or more times per day, things become murky.

Where to Buy GHRP-2

GHRP-2 is quite cheap when you compare it to other peptides and SARMs.

As previously stated, the short half-life of GHRP-2 is a real hurdle and has dissuaded many bodybuilders, including myself, from using it.

However, if you do want to buy pure and high-quality GHRP-2, you should check out my recommended list of peptide vendors.

They have independent third-party laboratories vetting their GHRP-2 and are generally a pleasure to deal with.

Conclusion

To be completely honest with you, I’m not that impressed with GHRP-2.

For someone that has a very active lifestyle, it’s a logistical nightmare to have to inject every couple hours.

I hope this impartial GHRP-2 review has shown you the true colors of this compound!

The post GHRP-2 Review, Benefits, Dosage | December 2023 appeared first on sarmguide.

TB-500 Review, Benefits, Dosage | December 2023

sarmadmin — Fri, 25 Mar 2022 19:24:30 +0000

In bodybuilding, as in life itself, injuries and pain unfortunately play a common role, hindering individuals from reaching their full potential.

Today, we’ll be doing a TB-500 review, where we’ll explore this quick-healing peptide and tell you:

What is TB-500
Is TB-500 legal
TB-500 in sports
TB-500 benefits
Where to buy the best TB-500
…and much more!

What is TB-500

Remember when you were a child, you would fall down and scrape your knee; the next day, the injury would be gone!

This is due to a protein in our body called Thymosin Beta-4, produced by the thymus.

This protein regenerates tissue, removes inflammation and helps cells move faster in the body.

It’s also called a BRM (Biological Response Modifier) because it modulates how our body responds to wounds and outside agents through the immune system.

There is no denying it, once you hit your 30’s, Thymosin Beta-4 production in the body drops significantly and pain and injuries start affecting you much more severely.

Enter TB-500, a synthetic version of Thymosin Beta-4, a peptide chain responsible for mimicking the effects of the protein above.

Discovered in the 60’s and first used on a human being in 1974 (a woman nonetheless), it has been studied for a long time, although actual human research is lacking.

TB-500 is speculated to be even stronger than Thymosin Beta-4 in its mode of action, owing to LKKTETQ, which is a key segment of TB-500 responsible for its benefits.

Another explanation is its low molecular weight, allowing for faster travel through the body.

How Does It Work

When entering the body, TB-500 exerts two main functions.

The first one would be increasing levels of actin in the body.

Actin is an essential component of every cell in your body and participates in cell motility, division, signaling and shape.

It basically plays a role in the structure of new cells, helps them move around faster and determines their form and function.

Actin also plays a key role in our muscle fibers, especially when it comes to muscle contraction and relaxation.

The two main cells affected by actin are our skin and blood cells, which explains the healing effect TB-500 has in the body.

Just like BPC-157, TB-500 promotes angiogenesis, which is considered to be essential for the formation of new blood vessels.

Not just that but angiogenesis is even being looked at as a tool to fight cancer and piqued the interest of scientists when it comes to dealing with cardiovascular disease.

Is TB-500 Legal

It is a shame that it has been more than 45 years since the first human tried TB-500, yet the FDA has made no progress in approving this peptide for human consumption.

Scientists are partly to blame for this too, as TB-500 research on humans is non-existent and explicitly reserved for horses.

The company behind TB-500 actually markets this peptide as a ‘horse healer’ and it is not recommended for human consumption.

However, this doesn’t mean that you can’t purchase TB-500 online for ‘your horse’ or for research purposes.

You don’t need to worry about the legality of purchasing TB-500 if you’re using one of the two reasons above.

In short, you can buy TB-500 without worry but you have to have the ‘right intentions’.

TB-500 In Sports

Here’s where a lot of irony comes into play; apparently, this untested peptide is banned by ALL sports organizations, including the WADA, USADA and ASADA.

If TB-500 doesn’t work and is ‘unsafe for human consumption’, why did its consumption become so widespread among athletes that the WADA had to step in and completely prohibit its usage?

Because it works wonders on wound healing and gives athletes who use it that much of an edge compared to those that don’t.

If you’re an athlete or are competing professionally, don’t use TB-500 as it has a long half-life and you won’t get away with it; they have perfected methods of finding it in the body.

Just like CJC-1295, TB-500 is crammed under ‘S2’ in WADA’s prohibited substance list, along with other peptides and similar compounds.

TB-500 Benefits

If you thought that the applicability of TB-500 was strictly reserved to wound healing, you would be sorely mistaken.

Let’s take a closer look at the top five benefits of TB-500!

1. TB-500 Stimulates Hair Growth

If you’re a bodybuilder on PEDs, this might be a particularly interesting benefit of TB-500.

Even if you’re not, hair loss is becoming an increasingly widespread issue for both genders and TB-500 can help out.

While scientists were studying rats who’ve suffered skin wounds, they unexpectedly stumbled upon hair growth in mice treated with the compound.

After the observation was confirmed, the researchers proceeded to shave mice and apply Thymosin Beta-4 topically.

Positive results were observed after just seven days, the mice were treated for an additional three weeks and no adverse effects were noted.

2. TB-500 Is Neuroprotective

We’re living in a world where the new virus actually affects brain function and cognitive skills.

Now more than ever is the time to take care of the most important organ in the body, your brain.

TB-500 has been shown to stabilize BBB (blood-brain barrier) function, which led to less cognitive decline and prevention of neurodegenerative diseases.

3. TB-500 Improves Wound Healing And Organ Injury

One way TB-500 promotes wound healing is by creating new blood vessels in the process of angiogenesis, which we mentioned earlier.

It has also shown itself to act as liver support, promoting blood flow through the liver, thereby helping patients suffering from liver fibrosis.

In a study done on injured rats, damage from oxidative stress and free radicals was prevented by the use of Thymosin Beta-4, inflammation was also much less pronounced compared to the control group.

4. TB-500 Decreases And Prevents Long-Term Inflammation

The key term to remember here is a term called autophagy, a process by which degraded cells are flushed out of the body and replaced by newer, healthier cells.

TB-500 prevents inflammation by promoting autophagy in the body.

Since autophagy also promotes homeostasis in healthy cells, it’s seen as a preventative measure in neurodegeneration and cancer.

The exact process by which TB-500 does all these things is still unknown but scientists believe it has to do with activating DAPK1 pathways.

DAPK1 is a protein enzyme responsible for regulating cells, both their emergence and their programmed death.

5. TB-500 Promotes Cardiovascular Health

Heart disease is the number one killer in the world and accounts for 1 in 4 deaths in the US.

TB-500 promotes cardiovascular health by increasing cell proliferation in the cardiovascular area.

It even stimulates vessel growth and prevents the death of healthy cells in the heart.

TB-500 Dosage And Cycle Length

It’s a tragedy that over 45 years have passed since TB-500 was first used and no human study ever mentions any dosages or appropriate cycle lengths.

Luckily, we have anecdotal reports dating as far back as the 80’s, when peptide usage wasn’t prohibited.

According to that data, TB-500 should be dosed once a week and the recommended dosage is anywhere between 1 to 8mgs.

From personal experience, we believe that the best dosage for newcomers to TB-500 would be 2mgs per week.

It’s a safe and effective dosage that shouldn’t produce any side effects.

If your pain or inflammation is chronic, feel free to take up to 5mgs per week but don’t go over that amount, as some people did report adverse effects at higher dosages.

Some anecdotal reports mention ‘loading’ and ‘maintenance’ phases but that’s not necessary and could lead to overconsumption, especially in first-time users.

TB-500 should be used for eight to twelve weeks and discontinued for at least a month, before starting a cycle again.

This ensures that you avoid dependency and the cumulative effects of TB-500!

TB-500 Half-Life

Since no human studies mention the half-life of TB-500, we have to assume it to be seven days or longer, at least that’s what the anecdotal reports say.

There is one interesting study that looked at the half-life of injectable Thymosin Beta-4 and they have determined it to be between 1 to 2 hours.

The study lasted for 14 days and it was observed that the more Thymosin Beta-4 the subjects injected, the longer the half-life ended up being.

Some may think this implies that multiple dosages of TB-500 per day may be needed to achieve optimal results but that is not the case.

The truth is, TB-500 has a stark effect on the body and taking it more than once per day does more harm than good.

TB-500 Side Effects

The lack of legitimate human studies severely limits our knowledge about all the potential side effects of this peptide.

When Thymosin Beta-4 was injected into humans, little to no side effects were found but it’s questionable whether the same applies to TB-500.

Here are the most common side effects of TB-500 according to anecdotal reports.

1. Headaches

Most commonly experienced a short time frame after injection, they go away on their own and no outside intervention is needed.

Also, nausea is not unexpected, so ensure that you’re not operating any heavy machinery after your TB-500 injection.

2. Potential Liver Injury In Obese Patients

This has only been tested on obese mice but is still included in the article as a safety precaution.

Perform a lipid panel once a month after you start your TB-500 injections to ensure everything is in order.

3. Flu-Like Symptoms

You will usually experience them around one to two hours after injection. They are uncommon but still happen to some people, so be prepared.

You don’t need to do anything special, just ensure that you’re in a safe environment and it will pass within a day.

We still don’t know the full range of side effects of TB-500, because of under testing and underreporting.

If you had an adverse reaction to TB-500 and would like to share the experience, feel free to comment under this article.

TB-500 VS BPC-157

Both of these synthetic peptides are known for promoting healing all around the body.

However, there are some differences between the two.

The first fundamental difference would be their half-life, BPC-157 is known for its low half-life and one has to imbue it up to three times a day to get the full range of effects.

On the other hand, TB-500 has a half-life of at least seven days and is administered once weekly.

Another difference would be their mechanism of action; TB-500 promotes cell regeneration through increased actin function, while BPC-157 mainly works by blocking 4-Hydroxynonenal.

They do share a common trait and that is angiogenesis.

Regarding potency, we would say that both peptides are somewhere in the same ballpark if taken as prescribed.

Their benefits might be similar but they do have some unique traits of their own.

For example, TB-500 increases hair follicles, while BPC-157 stabilizes blood pressure.

All in all, both of these compounds are potent peptides and are great at healing and rejuvenation.

Where to Buy TB-500

One would think that the most logical route of obtaining TB-500 would be straight from the company that produces it.

However, that is not the case for several reasons.

First of all, the company that makes it is known for doing background checks on their customers; unless you own a couple of horses, they won’t sell TB-500 to you.

If you think you can outsmart them by saying you’re a research company, be prepared to be asked for credentials as well as proof of address for your supposed laboratory.

Last but not least, the company doesn’t ship internationally which means that some customers will be excluded from the start.

There is no need to fret, as there are legitimate peptide vendors out there that sell 100% pure TB-500, you just need to know the right sources.

The good news is, our recommended list of peptide vendors contains the absolute best TB-500 sources on the market.

Not only are their products pure and lab-tested, you won’t need to jump through any hoops to buy your desired research chemicals.

Enjoy same-day shipping, worldwide delivery and absolute discretion!

Conclusion

If this TB-500 review has taught us anything, it’s that human research and scientific funding are seriously lacking when it comes to peptides.

It’s much easier (and more profitable) to get people hooked on painkillers, rather than provide a relatively safe and effective way to get rid of pain and suffering.

To sum up, TB-500 has been used for over 40 years and nothing bad has happened to anyone using it. It’s safe, well-tolerated and very efficient.

The post TB-500 Review, Benefits, Dosage | December 2023 appeared first on sarmguide.

Ipamorelin Review, Benefits, Dosage | December 2023

sarmadmin — Fri, 25 Mar 2022 19:06:30 +0000

Strong interest has been shown in this peptide, piquing the minds of ordinary people, budding bodybuilders and even top-performing athletes!

This Ipamorelin review will do a deep dive on this selective growth hormone secretagogue, showing you exactly:

What is Ipamorelin
Is Ipamorelin legal
Ipamorelin benefits
Ipamorelin dosage
Ipamorelin side effects
Where to buy the purest Ipamorelin
…and much more!

Read on to find out why thousands of people every year decide to start taking this peptide.

What is Ipamorelin

Since the dawn of science, researchers were always looking for ways to produce compounds that will exert positive effects while minimizing side effects subjects experience upon consumption.

It’s one of the founding stones of science but compounds with the above characteristics are very rare.

Introducing Ipamorelin, a synthetic pentapeptide that selectively targets GH levels in the body, without increasing cortisol levels or inducing side effects usually associated with growth hormone secretagogues.

Ipamorelin mimics the action of GHRP (growth hormone releasing peptides), which in return stimulates growth hormone secretion.

Moreover, it’s miles better than any known GHRP till date; it does the job of a GHRP more effectively and with less side effects!

Its selective nature ensures that it doesn’t harm any other organs in the body, such as the liver, and it very much reminds us of SARMs, who are also selective in their mechanism of action.

As an added bonus, Ipamorelin doesn’t affect prolactin, gonadotropins or pituitary hormones like thyrotropin.

This makes it the safest peptide till this date!

How Does It Work

First and foremost, Ipamorelin is a ghrelin mimetic, which means that it increases its levels in the body.

When people hear the word ghrelin, the first thing they think of is increased hunger, a very known side effect of ghrelin abundance.

However, as we’ll see in the benefits section below, ghrelin is much more than just a hunger hormone and exerts many important functions in the body.

Its second mechanism of action entails the release of GH into the body, which produces a myriad of benefits.

It does so through binding to GHRF (growth hormone releasing factor), also known as somatocrinin.

Last but not least, it hinders somatostatin levels in the body, which are responsible for the inhibition of GH.

This leads to an even bigger increase in GH levels in the body!

Is Ipamorelin Legal

Ipamorelin and many other peptides have not been approved for human consumption by the FDA.

Human research exists but is limited and more time needs to pass before this peptide gets the approval it deserves.

You can buy Ipamorelin legally but strictly for research purposes, not for human consumption.

Vendors who’ve misbranded Ipamorelin in the past faced heavy fines and even prison time, as evidenced by the Smith case in 2016.

Don’t buy Ipamorelin for anything but research purposes and don’t buy from vendors that brand it as eligible for human consumption.

There is no need to worry, by the end of this article, we’ll show you a list of legitimate vendors that sell the purest Ipamorelin, exclusively for research purposes!

Ipamorelin In Sports

Ghrelin mimetics are completely banned by the WADA under section ‘S2 (2.3)’ and as an athlete, you are not allowed to use Ipamorelin.

Failure to comply with this rule will get you banned from active participation in tournaments, leagues, contests, competitions, etc.

It might also retroactively cause you to lose out on any accomplishments you’ve made in the past.

For brevity’s sake, just stay away from Ipamorelin and other peptides if you’re actively competing.

Drug tests are common and the WADA hands them out frequently and without mercy, so don’t play with fire.

Ipamorelin Benefits

Since Ipamorelin selectively targets GH receptors in the body, it produces a wide range of potent effects.

Let’s explore some of them!

1. Ipamorelin Increases Body Weight

If you’re someone struggling to put on an extra few pounds no matter how hard you’re trying to bulk, Ipamorelin is the peptide for you.

It increases ghrelin production which induces hunger, making you eat more frequently and in higher quantities.

According to a study performed on rats, administration of both Ipamorelin and GHRP-6 showed no marked increase in food intake or bodyweight after the first shot.

However, when Ipamorelin alone was administered multiple times, the rats ate a lot more, had more bowel movements and gained body weight.

2. Ipamorelin Increases Bone Health And Strength

Even if you’re not a bodybuilder, bone health is associated with higher resistance to fractures, stronger muscles (according to a study on women) and bigger overall strength.

As you age, your bones degenerate and expose you to a plethora of unpleasant side effects.

Luckily, a study confirmed what was speculated for very long; Ipamorelin increased bone density and strength in rats lacking glucocorticoids, which are basically the body’s natural anti-inflammatory agents.

3. Ipamorelin Prevents Muscle Atrophy Through Ghrelin Increase

Remember when we mentioned that ghrelin wasn’t just a hunger hormone?

According to research, ghrelin decreases the risk of heart attacks (the number one killer in the US) and it also prevents muscle thinning.

Say you’re sick and bed bound for a week or even a month and can’t go to the gym; Ipamorelin prevents muscle loss and muscle wasting.

Some researchers see it as a potential treatment option for osteoporosis but studies on this matter are lacking.

4. Ipamorelin Improves Sleep Through GH Release

If there’s anything adult humans can’t get enough of, it’s sleep.

We’re chronically deprived of it, be it because of all the blue light from our surrounding technology or our hectic and stress-filled lifestyles.

Good sleep helps with the formation of muscle mass, reduces body fat and brings a lot more benefits to the table.

GH not only helps you fall asleep faster but improves sleep quality, which leads to mornings where you wake up feeling refreshed and ready to seize the day!

Ipamorelin Dosage And Cycle Length

Since human studies are almost non-existent when it comes to Ipamorelin, we’ll mostly rely on one Phase II study that researched the effects of this peptide in bowel resection patients.

The trial lasted only seven days, with two injections being administered, on the first and last day of the study.

A dosage of 0.03mg per kg of body weight was used and by the end of the study, the scientists found Ipamorelin to be ‘well-tolerated’ among all 114 patients.

Using this study as a reference, a person weighing 80kgs should imbue 2,4mgs of Ipamorelin per week, just as in the study.

Ipamorelin was considered safe by the scientists, so you shouldn’t expect many side effects while using the dosage above.

However, anecdotal reports of bodybuilders who took more than 0.03mg per kg of body weight claim to have experienced some adverse effects. More on that later.

We recommend sticking to the dosages as outlined in the study above, as it’s both a safe and effective dosage.

Long-term Ipamorelin usage hasn’t been studied in humans, so we can’t say for sure if its continual consumption would lead to problems down the road.

Most people using Ipamorelin recreationally cycle it every two to three months; they take it for eight to twelve weeks and stop usage for at least four weeks.

One reason Ipamorelin is cycled is because of decreased responsiveness to the peptide. Basically, your anterior pituitary cells get desensitized to the effects of the compound.

To prevent this, a tolerance break is necessary!

Ipamorelin Half-Life

Ipamorelin has a half-life of only two hours.

Some people might get the wrong idea and think that bihourly injections would be necessary to notice any benefits from this peptide.

The reason why it’s eliminated from the body at such a rapid rate is that it turns into GH and ghrelin almost as soon as it’s administered.

Both of these hormones stay elevated in the body for up to seven days after an Ipamorelin injection, so taking it more than once a week is completely unnecessary!

Ipamorelin Side Effects

The one human study mentioned in the ‘dosage’ section is simply not enough to gouge all the adverse effects of Ipamorelin.

Yes, scientists gave this peptide the green light and didn’t notice any side effects but the study only lasted seven days!

Anecdotal reports from bodybuilders paint a different story and here is what they had to say about the side effects they experienced while on this peptide.

1. Changes in Blood Pressure

Hypertension (high blood pressure) is the most common complaint by people taking Ipamorelin.

Supposedly, after a three-month cycle, you can expect an increase of up to 20 mmHg.

Luckily, this is a rare side effect and only about 10% of people taking Ipamorelin ever get to experience it.

However, if you have had problems with blood pressure regulation in the past, we suggest moving on to another peptide.

2. Injection Site Swelling, Rash Or Redness

If you’re injecting Ipamorelin, reports of side effects such as swelling, redness around the area of injection and even rashes aren’t that uncommon.

Most of the time, it’s due to the inexperience of the person administering the peptide and has nothing to do with Ipamorelin as a compound.

3. Lightheadedness

Some people enjoy the ‘floaty’ feeling they get after administering Ipamorelin, others get scared.

This is a common side effect and goes away in less than 30 minutes after taking Ipamorelin.

You don’t have to do anything special, just ensure that you’re either sitting or lying down so you don’t accidentally injure yourself.

Other very rare side effects such as water retention and fever have been reported.

They shouldn’t be a concern to someone sticking to our dosage guidelines, as the two side effects mentioned above are a result of Ipamorelin overconsumption.

Where to Buy Ipamorelin

There are a lot of bunk peptides on the market these days and if you don’t know your onions, you’ll be lost in the deep sea of countless online vendors.

Many users have reported underdosed and overpriced Ipamorelin, lack of transparency by peptide companies and a fundamental problem with shipping and delivery.

To prevent that from happening to you, we have assembled a list of the best peptide vendors on the internet.

They test their Ipamorelin in independent third-party laboratories, post their lab results publicly and most importantly, they respect you as a customer.

We never had an issue getting our research chemicals from the companies on our list and neither will you!

Conclusion

One problem with many peptides these days, including Ipamorelin, is the lack of long-term human research.

Put simply, there isn’t enough funding for peptide research in the scientific community.

We hope to see that change in the future, as this Ipamorelin review has shown us that a selective GH secretagogue such as this one deserves way more recognition!

The post Ipamorelin Review, Benefits, Dosage | December 2023 appeared first on sarmguide.

CJC-1295 Review, Benefits, Dosage | December 2023

sarmadmin — Wed, 23 Mar 2022 17:04:05 +0000

Growth hormone (GH) is one of the most important compounds in humans, helping with the replication, regeneration, growth and development of every cell in your body.

This write-up introduces a peptide hormone, analogue and secretagogue of GH called CJC-1295.

In this CJC-1295 review, you will learn:

What is CJC-1295
Types of CJC-1295
The benefits of CJC-1295
CJC-1295 dosage and cycle length
CJC-1295 side effects
Where to buy the purest CJC-1295
…and much more!

What is CJC-1295

CJC-1295 is a synthetic peptide developed by ConjuChem Biotechnologies.

To properly explain CJC-1295, we first have to understand Sermorelin acetate, which is also a peptide; an analogue of GHRH (Growth Hormone Releasing Hormone) to be precise.

GHRH is used to gauge how much Growth Hormone is released by the body and is helpful in determining growth hormone deficiency.

The scientists at ConjuChem were looking to improve Sermorelin acetate in order to help patients suffering from insufficient amounts of GH.

After some experimenting, they created CJC-1295, a peptide with higher bioavailability and half-life compared to its predecessor.

The nickname of CJC-1295 should tell you all about its potency, it’s also called DAC:GRF, which stands for drug affinity complex : growth hormone-releasing factor.

Interestingly enough, CJC-1295 is composed of 29 amino-acids, which is almost twice as much as BPC-157, a popular peptide used for healing and wound tending.

How Does It Work

CJC-1295 has numerous effects on the body but it mainly works by stimulating the pituitary gland to release more GH and IGF-1, increasing serum concentration levels in the body by a marked amount.

Increased GH levels are often correlated with increase in lean body mass, better sleep, reduced inflammation, neuroprotective properties and increased Testosterone production.

Increased IGF-1 levels are associated with increased muscle mass, decreased fat levels and regenerative properties.

In humans, GH is secreted between eight to ten times per day, rhythmically.

CJC-1295 increases both the strength of the release, as well as decreasing the action of somatostatin, which is a growth hormone inhibitor.

Types of CJC-1295

There are two main types of CJC-1295 you see on the market, with or without DAC.

DAC stands for Drug Affinity Complex and was also developed by ConjuChem, so it’s not something a vendor or a third person is adding to the peptide.

Supposedly, CJC-1295 with DAC promises higher shelf life, longer half-life and better bioavailability.

On the other side of the coin, some people are concerned that CJC-1295 with DAC overloads the pituitary gland too soon, leading to GH resistance or even GHI (Growth Hormone Insensitivity).

Note that no study insofar has found any of the above to be true; quite on the contrary, both versions of CJC-1295 were tolerated quite well in both animal and human studies.

We don’t think you should concern yourself with what type you’re getting, they are both from the same company and they are both perfectly safe.

Is CJC-1295 Legal

In most countries, including the US, CJC-1295 is in a gray area, legally speaking.

It’s not yet approved for human consumption by the FDA, so it’s being marketed as a research compound.

This means that you can purchase CJC-1295 online without any problems but only as a research chemical for scientific purposes.

However, buyers should beware, as some countries have special laws governing peptides.

For example, in Denmark, peptides such as CJC-1295 have been confiscated and their use was described as ‘illicit’.

This is just one country out of many and shouldn’t concern you much but to be perfectly safe, check the local laws of your state/country.

CJC-1295 In Sports

Ten years ago, when nobody in the WADA paid much attention to peptides, it was basically a free-for-all.

Nowadays, the situation has changed drastically.

The WADA and USADA acknowledge the potent effect peptides such as CJC-1295 can have on the body and have since banned the compound.

In fact, Sport Integrity Australia has a special page dedicated just to CJC-1295, where offenders that have used or distributed the peptide are publicly named.

In the WADA handbook, CJC-1295 is considered prohibited and put under section ‘S2’, which denotes ‘peptide hormones, growth factors, related substances and mimetics’.

This should tell you all about the unfair advantages athletes get when they imbue peptides such as CJC-1295.

Speaking of advantages, let’s list the benefits of this peptide!

CJC-1295 Benefits

The release of GH and IGF-1 has so many benefits in the human body that an entire book wouldn’t suffice to cover the topic.

We’ll name the four biggest benefits tied to CJC-1295 alone and briefly mention the secondary perks of this peptide at the end of the section.

1. CJC-1295 Aids Fat Loss

Even if you’re not a bodybuilder, fat storages in your body can lead to serious diseases if in high enough concentrations over extended periods of time.

A study done on GHRH-KO mice showed that administering CJC-1295 once daily helped normalize prolactin levels, which are associated with fat loss, even in human subjects.

Prolactin slows down your overall metabolism which can lead to fat and plaque accumulating in your blood, leading to cardiovascular disease.

Luckily, even if you’re suffering from high prolactin levels, CJC-1295 has been shown to quickly regulate its levels, leading to a reduced chance of problems occurring down the road.

2. CJC-1295 Increases IGF-1 Levels

We’ve already mentioned all the benefits of increased IGF-1 levels but we didn’t say a word about the possible side effects of elevated IGF-1 levels.

The interesting thing is, CJC-1295 does not change the body’s pulsatile (rhythmic) IGF-1 secretion timing, which means that usual side effects associated with IGF-1 simply don’t occur.

However, what has to be noted is that researchers were expecting the compound to be even stronger in its effects on IGF-1 levels (only a 40% increase was observed, instead of the expected 75%).

Despite that, no side effects is a far better trade off compared to higher IGF-1 levels, which means that CJC-1295 passes the test with flying colors.

3. CJC-1295 Increases GH Secretion

Our growth hormone is responsible for growth all over the body and its function doesn’t stop once our teenage years are over.

Moreover, it affects bone density, muscle mass, fat storage (especially around the stomach) and cholesterol levels.

CJC-1295 increases serum concentration levels of GH in the human body by up to 50%.

4. High Bioavailability Compared To Other GH Secretagogues

A compound can show excellent results in cellular and even animal studies but if it’s not absorbed by the human body at a high enough rate, it all amounts to nothing.

CJC-1295 is one of the most bioavailable GH secretagogues available on the market.

The company behind this peptide used recent advances in molecular biology, utilizing a process called bioconjugation.

Bioconjugation happens when two molecules are fused together, in this case, two proteins, in order to increase stability, bioavailability and drug tolerability.

If you thought this was it when it comes to the benefits of CJC-1295, you haven’t even seen half of it.

More than 100 studies have shown that GHRH analogues (such as CJC-1295) have the following additional benefits in the human body and mind:

Improved cardiovascular function
Increased muscle mass
Increased fat loss
Neuroprotective properties
Nootropic effects
Better mood and decreased depression
Wound healing and tissue repair
Improved recovery times
Increased protein synthesis
Better sleep
Better skin, nails, hair
…and a whole lot more!

CJC-1295 Half-Life

Over 90% of CJC-1295 entering the body ends up binding to albumin, a liver protein which transmits this peptide throughout the body.

Not just that, it also prevents CJC-1295 from escaping your bloodstream and therefore, CJC-1295 has one of the longest half-lives of all the peptides.

Although no study mentions the exact half-life of CJC-1295, it’s estimated to be around seven days.

CJC-1295 Dosage And Cycle Length

Peptides are usually consumed in miniscule levels, such as micrograms (not to be confused with milligrams!).

Since CJC-1295 is usually injected and has a long half-life, you won’t need to use it more than once a week to feel the full range of effects.

Studies on humans are sparse but from the literature available; especially a study performed in 2006, dosages between 30 to 60 mcgs per kg of body weight were tolerated quite well and no adverse effects were found.

What does this mean for a fully grown human?

Say you weigh 90kg and are opting for the low end of the spectrum to keep things safe.

You would multiply 90 by 30mcgs and get 2700mcgs of CJC-1295 per week.

Ensure that you’re using a precise measuring tool if you’re consuming liquid CJC-1295.

While no overdoses have been reported, it’s best to not test the waters when it’s not necessary.

Last but not least, it’s important to note that CJC-1295 accumulates in the body over time, so one thing can’t be stressed enough; you have to cycle it!

A twelve week CJC-1295 cycle followed by a month of no peptides at all should do the trick, according to anecdotal reports.

The best time to take CJC-1295 would be before going to bed, as it can cause increased hunger in subjects who’re imbuing it.

CJC-1295 Side Effects

The study we mentioned above was performed on healthy human volunteers and they experienced no side effects at all from CJC-1295 usage.

That is to be expected due to the fact that it doesn’t strain the pituitary gland as much as other GH secretagogues.

However, some anecdotal reports point to side effects seen in first time users and in those who took too much at once.

1. Vertigo

If you’re feeling like the room is spinning or are having headaches after you imbue CJC-1295, you should lower your dosage.

However, if it’s your first time taking CJC-1295, it’s just your body reacting to a foreign substance it has never met before.

These side effects go away after just a couple of doses and should not concern the user.

2. Increase In Body Temperature

A very rare side effect experienced when the user takes too much CJC-1295 to begin with.

No medical intervention is needed as it goes away on its own.

3. Mood Swings

Another rare side effect, most prominent in those already suffering from psychiatric disorders (especially mood disorders).

If you have a history of mental illness, consult your local healthcare provider before starting CJC-1295 or any other peptide.

Peptides like CJC-1295 can interact with certain medications and make them less effective or in some cases, more potent.

CJC-1295 VS Ipamorelin

Vendors often offer these two peptides together in a stack.

Is that done to increase revenue or is there really a benefit to stacking them together?

In our opinion, it’s not necessary to stack CJC-1295 with Ipamorelin since both of these peptides are strong enough on their own and exert potent effects on the body.

One downside of stacking both of these peptides is the increased risk of side effects, although both compounds are generally considered to be safe and well-tolerated.

To conclude, it’s best to pick one of them and stick with your decision, as consuming multiple GH secretagogues at once could lead to overstimulation of the pituitary gland.

Where to Buy CJC-1295

No doctor is going to bother prescribing CJC-1295 to their patients, so the best and fastest way to obtain CJC-1295 is to buy it online.

Buying peptides online can be a giant headache, since there are literally hundreds of options to choose from.

If you were to do your due diligence, it would take you months, maybe even years, to find a vendor worthy of consideration.

Luckily for you, our team of experts has bought and tested CJC-1295 from dozens of vendors.

While most of them didn’t pass our rigorous testing routines, there are a couple out there that are doing things right.

To get the best and purest form of CJC-1295, check out our recommended list of peptide companies.

It’s an exhaustive list of legitimate peptide companies that care and respect the integrity and anonymity of their customers.

Conclusion

All in all, this CJC-1295 review has shown you all you need to know about this peptide.

While there haven’t been a lot of human studies performed with CJC-1295, it’s a very promising peptide due to its high bioavailability, half-life and potent effects.

It’s one of our favorite GH secretagogues due to the fact that it doesn’t produce the usual side effects experienced when imbuing such compounds.

The post CJC-1295 Review, Benefits, Dosage | December 2023 appeared first on sarmguide.

BPC-157 Review, Benefits, Dosage | December 2023

sarmadmin — Wed, 23 Mar 2022 16:46:19 +0000

It doesn’t matter if you’re a bodybuilder or just someone suffering from pain due to wounds, inflammation or infections, BPC-157 can step in and help out.

This BPC-157 review will show you exactly how to use this peptide to its fullest potential and also:

What is BPC-157
BPC-157 benefits
The proper BPC-157 dosage
Where to buy the best BPC-157
…and much more!

Let’s introduce the compound before talking about its mechanism of action, benefits and other important details.

What is BPC-157

Scientific literature sometimes uses the terms Body Protection Compound (BPC) and BPC-157 synonymously but they are not one and the same.

There is a difference between BPC, which is a protein found naturally in the human body and BPC-157, which is much shorter than the former and an iteration of BPC.

BPC-157 is a synthetic peptide, first discovered in the 90’s; it’s quite short as a peptide as it only has fifteen amino-acids.

However, this doesn’t affect its potency in any way, moreover, its therapeutic potential excites scientists and the compound is being studied till this day.

How Does It Work

When introduced into the body, BPC-157 starts promoting angiogenesis, which is the formation of new blood vessels from existing ones.

It all starts with the increase of a protein called VEGF (vascular endothelial growth factor).

Not only does this protein help with angiogenesis but also with vasculogenesis; the two are closely related to one another and are quintessential for supplying oxygen and blood to tissue affected by injury.

There are three main types of VEGF and they are all modulated by BPC-157.

Moving on, BPC-157 blocks 4-Hydroxynonenal, which is a byproduct of oxidative stress, known to be related to many diseases but mainly, cell death.

4-Hydroxynonenal is considered to be pleiotropic, which means that it exerts multiple effects, especially when diseases related to oxidative damage in the body are concerned.

By blocking it, BPC-157 promotes faster healing and tissue regeneration.

4-Hydroxynonenal also stops cell growth, which is why people with lower concentrations of this compound recover way faster!

BPC-157 can also be seen as somewhat of a nootropic.

It modulates two of the most important neurotransmitters in the brain, dopamine and serotonin.

Research on mice shows elevated levels of those two neurotransmitters shortly after BPC-157 administration, which may explain why it’s considered as an agent against depression.

Last but not least, BPC-157 can reduce blood pressure by increasing nitric oxide production.

Nitric oxide widens blood vessels and even releases human growth hormone, which has a myriad of benefits!

Is BPC-157 Legal

BPC-157 hasn’t been approved for human consumption by the FDA.

The compound is still too new and research is actively being performed, with mostly positive results.

However, this doesn’t mean that it’s illegal to buy it.

It’s possible to get BPC-157 with a doctor’s prescription or buy it online but for research purposes only.

The latter is the easiest and most cost-effective option, more on this later on.

BPC-157 In Sports

If you’re an athlete or participate in professional sports, you should definitely avoid BPC-157 and any of its derivatives.

The reason being the inclusion of BPC-157 in the WADA handbook of prohibited substances.

According to their list, BPC-157 is a ‘non-approved substance’ and marked as ‘S0’.

Many athletes have (ab)used BPC-157 for its amazing benefits on both the body and brain.

It went as far as the WADA having to step in as it was noted that BPC-157 provided athletes with an unfair advantage over their competitors.

This should tell you all you need to know whether it really works on humans!

BPC-157 Benefits

A book could be written about the positive effects of BPC-157 on the body.

Since this is a website mainly focused on bodybuilding, we’ll aim to highlight those benefits first and foremost.

Before starting, a common misconception about BPC-157 has to be addressed; rumors claiming only cellular and animal studies have been done on this compound.

That is not entirely correct, as Phase II human trials are on the way and what’s even more interesting, BPC-157 is being looked at as a potential remedy for the virus currently ravaging our world.

With that out of the way, let’s get started!

1. Improves Muscle And Tendon Healing

If you’re a bodybuilder, you know how easy it is to injure yourself and shave off weeks of training from your regime.

That should no longer be a concern once you introduce BPC-157 into the fray; its healing properties have been confirmed in a placebo study on rats.

The healing has been described as ‘rapid’, even when bigger injuries were at play.

Another study gave rats corticosteroids (basically drugs that mimic cortisol), which should present a hindrance when it comes to muscle healing.

However, BPC-157 prevailed without a problem and proved itself effective in healing muscle tissue that had literally been cut from rats.

2. Improves Recovery Times On All Types Of Injuries

The first benefit highlighted muscles and tendons, but this one is more far-reaching; BPC-157 has shown to improve recovery rates, no matter what the injury entails.

One way of doing so is by increasing blood flow in the body, which was a talking point we covered in a previous section.

Delivering blood to damaged tissues is quintessential as it provides nourishment to the wound, imagine it to be a cocktail of oxygen and other nutrients necessary for recovery.

Another way is by increasing blood cell proliferation through VEGFR-2, which is the main pathway for the aforementioned angiogenesis.

3. Reduces Inflammation

Inflammation is a common problem in bodybuilding, especially when it’s acute or chronic.

It can completely hinder your ability to function normally.

BPC-157 has been shown to reduce inflammation, even the chronic kind, in both people with IBD (Inflammatory Bowel Disease) and in healthy volunteers.

Other tests and studies were also performed, where BPC-157 went under the code name ‘PL 14736’ (denoting the name of the research company, Pliva) and positive results have been observed.

4. Acts as a Neurprotectant and Antidepressant

If days where you simply don’t want to get out of bed and into the gym seem to be on the rise, it could indicate that your dopamine levels might need a boost.

Not just that but as we age, not just our body but also our brain starts degenerating.

We notice brain fog, forgetfulness, low concentration and a host of other, unpleasant experiences.

BPC-157 has been shown to boost neurotransmitter count (especially dopamine) and reduce depressive behavior in rats.

A study where rats exposed to chronic stress were given either BPC-157 or imipramine and nialamide (common antidepressants).

The results of the study were very promising; BPC-157 held its own against these two antidepressants and the results from all groups were similar.

Moreover, antidepressants took more time to start working and have shown more side effects in the rats.

Its role as a neuroprotectant is also not to be underestimated.

It helped prevent seizures, brain damage and it increased neurogenesis (the formation of new brain cells).

5. Stabilizes Blood Pressure

We already talked about BPC-157 lowering high blood pressure through NO increase.

What we failed to mention is the fact that, if you’re suffering from low blood pressure, BPC-157 actually increases it!

This means that it acts as a potent blood pressure stabilizer.

Why is this important?

Say you’re a bodybuilder on PEDs, some PEDs will cause changes to your blood pressure, which could lead to problems down the road.

One of the easiest ways of mediating this side effect is by introducing BPC-157 into your protocol!

These are the five main benefits of BPC-157 on bodybuilders.

We didn’t mention its positive effects on the health of your heart, gut, drug intoxication, liver damage, stomach lining and treating abnormal amounts of potassium in your blood.

To conclude, BPC-157 is one of the most beneficial peptides out there and as more human studies roll out, we hope to see an increase in its usage.

BPC-157 Dosage And Cycle Length

BPC-157 is effective in very low dosages, we’re talking about mcg (micrograms, not milligrams) here.

Most people take it between two to three times per day, due to its low half-life, which is purported to be four hours.

Dosages used on rats ranged up to 10mcgs per kg of bodyweight, which would translate to around 700mcgs for an adult weighing 70kgs.

However, humans and mice are not the same, just because a dosage provides optimal results on mice, doesn’t mean it will do the same for humans.

To cut it short, dosages don’t overlap.

From the research available on humans, as well as many anecdotal reports, you won’t need more than 400mcgs per day to feel the full range of effects.

It’s best to start off with 100mcgs taken twice per day and work your way up from there.

Many people like to cycle BPC-157.

They usually take it between eight to twelve weeks before halting usage for two to four weeks.

The best way to utilize BPC-157 would be to take it until the pain, inflammation, depression or other ail subsides.

You don’t have to worry too much about side effects, as all studies, both on animals and humans, point to the fact that it’s very safe and tolerated quite well.

BPC-157 Side Effects

As mentioned earlier, this peptide is considered to be very tolerable and quite safe for usage, even for extended periods of time.

Some studies used BPC-157 on rats for months and no adverse effects were detected.

However, peptides in general have side effects that are not often talked about.

Unfortunately, this includes BPC-157.

Let’s list some of them and provide examples as to how to best handle them.

1. Headaches and Nausea

This side effect is very prominent in first time users, it’s just our body getting used to the compound and shouldn’t concern you.

However, if the headaches and nausea are severe, consider lowering your daily dosage.

2. Increased Hunger

This is a godsent to some but to others struggling with excess weight, it’s a nightmare.

Time your BPC-157 usage to avoid food cravings during the day if you’re a part of the latter group.

3. Heightens/Lowers Effects of Other Medications

This especially rings true if you’re using antihistamines, antipsychotics, antidepressants or anxiolytics.

If you’re using any of the above, consult your doctor before starting a BPC-157 protocol.

4. Not Recommended In People With Active Cancer

If you are unfortunately dealing with cancer, it is not recommended you take BPC-157, even if you’re in pain.

Even though no study has ever confirmed that BPC-157 leads to cancer cell proliferation, you can’t be too careful.

The mainstream theory suggests that since BPC-157 improves blood flow, it should also technically feed cancer cells, allowing them to grow faster.

Once again, this hasn’t been proven in any study.

On the flip side, BPC-157 is being researched as a potential aid in osteoporosis and cachexia caused by cancer.

Research is still in the early stages, so to be 100% safe, stay away from BPC-157 and other peptides if you’re suffering from cancer.

How to Take BPC-157

If you’re intrigued by this peptide and are interested in all the ways you can use BPC-157, then the following information will prove pertinent to you.

1. Nasally

One of the safest ways of getting BPC-157 into your system is via your nasal passage. It might not be the most effective way but it’s still potent enough that people all over the world do it.

2. Orally

Taking liquid BPC-157 orally might leave a chemical taste in your mouth, that’s why some vendors add aroma compounds (lipolyzers) to the fray to make it taste better.

Our suggestion would be to wash BPC-157 down with some orange juice or water, whichever you prefer.

If you’re using capsules, the taste shouldn’t worry you, just make sure that you read the labels and accurately gouge how much BPC-157 you’re actually imbuing.

3. Subcutaneously

A needle containing BPC-157 is administered directly on the spot that’s in need of healing.

Injecting BPC-157 (and other peptides) proves to be the most effective way of using them and promises excellent bioavailability.

The problem is, if you’re afraid of needles or are wary of injecting yourself, you’ll not really like this method.

4. Intramuscularly

By far the quickest way to get BPC-157 into your system, since it travels directly into your bloodstream from the injection site.

We don’t recommend doing this on your own, as it can be quite painful and requires some precision.

Discuss this option with your healthcare provider if you really want to take BPC-157 through this route.

Where to Buy BPC-157

Since most peptides used get injected by the person in need of them, it’s very important that your peptide source provides the highest-quality products.

We’re here talking about BPC-157 that’s pure, cleared of any chemicals or radicals and not mixed with anything else.

Basically, you’re looking for 100% pure BPC-157.

In the process of obtaining BPC-157, we tested over 50 peptide vendors and their products; most of them were not satisfactory and we cannot recommend them.

However, a few vendors do care about quality; they test their products in third-party laboratories, are made in the US and most importantly, they are free of any chemicals which might contaminate BPC-157.

Take a look at our recommended list of Peptide vendors and make a choice depending on what type of BPC-157 you prefer.

We are very keen on using liquid BPC-157 orally or BPC-157 capsules, since you reduce risk of injury down to zero.

Conclusion

BPC-157 is a very strong peptide with healing capabilities that far outshine traditional methods.

Most importantly, it doesn’t cause addiction (unlike most painkillers), it’s safe to use and there’s a quick onset of positive effects.

To conclude this BPC-157 review, a very promising peptide with a bright future ahead of it!

The post BPC-157 Review, Benefits, Dosage | December 2023 appeared first on sarmguide.